The project is a collaborative effort of the laboratories of Prof. Dr. Achim Weber and of Prof. Dr. Anne Müller, and the prospective candidate will be affiliated with both the University Hospital and the University of Zurich.
Our shared project focuses on the molecular and bacterial drivers of gastric carcinogenesis, which we study using human biopsy material, mouse models and organoid and cell culture systems. We are particularly interested in the role of the bacterial carcinogen Helicobacter pylori as a driver of gastric malignancy. The project comprises morpho-molecular characterization of human gastric cancer tissues in comparison with normal gastric tissue, in conjunction with genetic manipulation of cell cultures and organoids, to test the hypothesis that early predisposing mutations synergize with pathogenic Helicobacter strains to promote malignant transformation. Hypotheses resulting from these approaches will be tested in suitable mouse models.
The candidate will conduct experiments involving morphologic analyses, molecular biology, genome editing, and work with animal models.
We expect the successful candidate to take utmost advantage of a team of basic and clinical scientists. Applicants with a strong theoretical and practical background in cancers of the gastrointestinal tract are encouraged to apply. Experience in organoid cultures (of any origin), mouse models of cancer and genome editing is a plus. We expect a strong interest in and dedication to science and the ability to independently develop and drive a research project. Candidates should hold a PhD, MD-PhD or equivalent degree in life sciences, or should have advanced or completed specialist training in pathology.
What we offer
Two years of full funding, excellent research labs and facilities and close collaboration in a translational setting.
Place of work
Start of employment
The starting date is April 1st, 2020
Applications will be accepted until February, 29th.