The research group of Prof. Alexandra Trkola is based at the Institute of Medical Virology, University of Zurich, Zurich, Switzerland. The main focus of the group is on defining processes that lead to broadly neutralizing antibody (bnAb) responses in HIV-1 infection to enable the design of bnAb based vaccines. Investigating bnAb activity alongside viral, immunological and genetic factors in large cohorts of HIV-1 infected individuals, we generate comprehensive data sets that allow unraveling parameters and predictive biomarkers of bnAb induction. Our research is highly translational and feeds on close collaborations with clinicians (group Prof. Huldrych Günthard, University Hospital Zurich) and experts in mathematical modeling and biostatistics (group Prof. Roger Kouyos, University Hospital Zurich). The groups Trkola, Günthard and Kouyos jointly offer a Post Doctoral position in computational vaccinology to complete our team of molecular biologists, immunologists, infectious disease specialists, mathematicians and biostatisticians.
The candidate will develop, apply and optimize cutting-edge bioinformatics and machine learning methods to further our understanding of HIV-1 bnAb induction. Development of computational methods using deep learning will be used to identify predictive biomarkers and factors directly involved in bnAb induction. A large emphasis of the work will be on deciphering genetic fingerprints of the HIV-1 envelope gene that are linked with bnAb induction to foster the development of effective immunogens.
You should have a strong background in computer science, biostatistics, bioinformatics, computational biology or related disciplines and be versed in biology and genomics. Excellent proficiency in R, data base management and profound experience in analysis of complex data are required. You enjoy working in an inter-disciplinary team. You have excellent presentation and English language skills, and are experienced in writing scientific papers.
What we offer
An attractive position in a stimulating, dynamic research environment with state of the art computational resources and modern equipment.
- Employment at the University Zurich, a renowned life sciences hub in Europe
- A salary according to the regulations of the Swiss National Science Foundation (www.snf.ch) will be offered.
Place of work
Institute of Medical Virology, Winterthurerstrasse 190, 8057 Zürich
Start of employment
Employment start date to be mutually agreed.