Postdoctoral and Academic Positions at the Oklahoma Medical Research Foundation, is an independent, nonprofit biomedical research institute, United States
Data Analyst / Bioinformatics Specialist
The Nath laboratory is seeking a highly motivated, self-starter senior level scientist with the ability to work with optimal resources and little direct supervision to address important questions in the genetics and genomics of systemic lupus erythematosus (SLE or lupus), an autoimmune disease. Using large-scale genome wise association studies (GWAS), our lab has identified several genes/genetic variants associated with lupus susceptibility. Now we are trying to understand the specific functional effects of those lupus associated genetic variants, using cell lines from patient-derived primary immune cells or tissues. We will apply various modern techniques for studying features of three-dimensional (3D) genomic organization such as 3C, Hi-C, ChIP-Seq, RNA-seq and genome editing using CRISPR/Cas9 based techniques. Successful candidate will be proficient in a wide range of analytical methods and the use of bioinformatics/genetics software for analyzing and interpreting various types of data.CategoryScientific ID2021-1034 ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Postdoc/Assistant Staff Scientist – Genetics of Lupus
The Nath laboratory in the Arthritis and Clinical Immunology research program is seeking a highly motivated, self-starter staff-scientist/post-doctoral level with the ability to work with optimal resources and little direct supervision to address important questions in the genetics and genomics of the systemic lupus erythematosus, an autoimmune diseases. Successful candidates will be proficient in wide range of contemporary molecular biology techniques such as, high-throughput sequencing of DNA, RNA, and methylation, ChIP-Seq, ChIP-qPCR, Single cell genomics, flow cytometry, cloning, cell culture etc. Experience in genome CRISPR/Cas9 or similar approaches will get preference. Competitive individuals will also have some experience in the analysis of genetic data, high-throughput sequencing data and the use of bioinformatics software.CategoryScientific ID2021-1057 ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Postdoc/Assistant Staff Scientist – Lupus
The Nath Lab is seeking a highly motivated, hardworking and organized team player (Post-doctoral Fellow / Assistant Staff Scientist) to join our effort to understand genetic mechanisms of lupus, an autoimmune disease. Using whole genome search, our lab has identified several genes/genetic variants, associated with lupus susceptibility. Now we are trying to understand the specific functional effects of those lupus associated genetic variants, using cell lines, patients-derived primary immune cells or tissues. We will apply various modern techniques for studying features of three-dimensional (3D) genomic organization such as 3C, Hi-C, ChIP-Seq, and genome editing using CRISPR/Cas9. Candidate will be involved in the analysis of human genetic data and the development of computational methods, which requires a mix of computational skills, statistical knowledge, creativity and biological insight. Specifically, candidate will identify novel therapeutic targets and biomarkers from the investigation of human genetic variation (GWAS, Next Gen Sequencing) with disease status and intermediate variables using cutting-edge techniques in Statistical Genetics. Candidate will develop and apply methods for the integration of GWAS summary results with other types of data e.g. eQTL, mQTL, functional genomic annotations, gene networks, estimation/partitioning of heritability, Mendelian Randomization to understand causal direction, and fine mapping. Candidate will collaborate with experimental and clinical scientists to address target mechanism specific questions and seek to support investment decision making with genomic insights.CategoryScientific ID2021-1058 ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Postdoc – Analyst Bioinformatics
The Lessard lab is seeking a Post-doctoral Fellow with experience in computational sciences to join our research team. Our research investigates the regulatory functions that control gene expression within the complex landscape of the three-dimensional genome and how genetic variations influence these regulatory functions to cause human diseases such as Sjögren’s syndrome, systemic lupus erythematosus (SLE), and other autoimmune diseases. We perform a wide variety of high-throughput sequencing technologies in both bulk and single cell technologies: genotyping arrays, RNA-seq, single cell (sc)RNA-seq, Perturb-seq, long sequence Nanopore sequencing, spatial transcriptomics, etc. In addition, we leverage gene-editing technologies, i.e. CRISPR/Cas9 editing, to functionally characterize non-coding regulatory regions of the genome in the context of native 3D chromatin regulatory network using 3C technologies (3C-qPCR, etc.) and promoter capture Micro-C. Candidate must demonstrate proficiency in computer programming (UNIX-like OS, R, and python), and the application of statistical methods commonly used to analyze genetic data. Experience using data analysis pipelines and machine learning analytical approaches is a also preferred. Candidates must also demonstrate an ability to interpret and summarize research findings, and interest in assisting manuscript preparation and grant writing, and presenting at scientific meetings.CategoryScientific ID2022-1364 ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Postdoc – Cellular Metabolism
The laboratory of Dr. Pengchun Yu in the Cardiovascular Biology Research Program at the Oklahoma Medical Research Foundation (OMRF) is seeking postdoctoral scientists. We focus on the interface between cellular metabolism and vascular biology and have a proven track record in this field (Circulation Research, 2010; Circulation, 2012; Nature, 2017; J. Biol. Chem., 2021). More information about the lab can be found at https://yulab.omrf.org/. The successful candidates will work on research projects that study the crosstalk between metabolic programs and angiogenic signaling and the involvement of cellular metabolism in the pathogenesis of vascular diseases. Multidisciplinary strategies will be used, ranging from novel genetically modified mouse models to cutting-edge systems biology tools including metabolomics and single-cell transcriptome analysis. OMRF is an independent, nonprofit biomedical research institute. The innovative basic and translational research at OMRF covers several critical areas such as cardiovascular disease, autoimmune disease, and cancer. OMRF has made The Scientist magazine’s annual list of the “Best Places to Work for Postdocs” for many years. The institute offers postdoctoral fellows an exceptional research and training environment with state-of-the-art facilities and outstanding core technology laboratories including imaging, next-generation sequencing, and clinical genomics. Moreover, postdoctoral scientists are encouraged to apply for OMRF Postdoc Travel Awards to support their attendance at meetings or workshops.CategoryScientific ID2022-1373 ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Research Technician / Research Technician II / Research Technician III
The Yoon Lab is looking for a highly motivated, organized, responsible person who will play a key role in achieving the mission of the lab. Using Drosophila (fruit fly), we aim to discover cellular and molecular mechanisms how metabolic dysfunctions cause human diseases including neurological diseases. We utilize variety of approaches including genetics, metabolomics, biochemistry, cell and molecular biology as well as confocal and electron microscopy. Responsibilities will include: – Maintenance of Drosophila stocks – Conducting genetic experiments to assess gene function in Drosophila – Prep of Drosophila tissue samples and imaging using fluorescent and confocal microscopes – Conducting basic molecular biology experiments such as PCR and cloning – Detailed documentation of experiments and results – Participation in lab and departmental meetingsCategoryLaboratory ID2022-1452 ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Assistant Professor
The Genes and Human Disease Research Program at the Oklahoma Medical Research Foundation (omrf.org) invites candidates to apply for an investigator position at the Assistant Professor level. Current investigators in GHD study questions related to human disease through both model organism and human studies. Our expertise varies from stem cell biology, genome editing, genomics bioinformatics, and neuroepigenetics to human health-related problems including autoimmune diseases, aging, hearing loss, and regeneration. We seek to identify a candidate who will establish an independent research career as well as catalyze collaborative research in our highly interactive program. All investigators at OMRF have access to state-of-the-art core facilities, including an Imaging Core, animal facilities, and modern, next generation sequencing technology and bioinformatics platforms. The successful candidate will receive a generous, multi-year, start-up package with significant salary, equipment, and research funding. OMRF also provides substantial ongoing salary support and research support after the start-up period has ended. OMRF is an independent, not-for-profit biomedical research institute adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City. Oklahoma City offers a dynamic and burgeoning midtown area near the campus, and a very reasonable cost of living. We are committed to addressing additional needs of faculty, including dual career couples and single parents. We are particularly focused on overcoming barriers to gender equity in science. OMRF is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to gender, sexual orientation, gender identity, race, color, national origin, age, religion, disability, veteran status, or any other legally protected characteristic.CategoryScientific ID2022-1461 ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Research Technician/Research Technician II
The Yu Lab at the Oklahoma Medical Research Foundation (OMRF) is seeking a highly motivated individual to join our team. We are part of the Cardiovascular Biology Research Program at OMRF. Our research focuses on the interface between cellular metabolism and vascular biology. Specifically, we aim to elucidate the crosstalk between metabolic programs and angiogenic signaling events and to understand the involvement of cellular metabolism in the pathogenesis of vascular diseases. Multidisciplinary strategies will be employed, ranging from novel genetically-modified mouse models to cutting-edge systems biology tools including metabolomics and single-cell transcriptome analysis. Responsibilities will include: – Mammalian cell culture and genetic manipulation – Biochemical and cell biology experiments to assess gene expression and function – Mouse tissue dissection, immunohistochemistry, and confocal imaging – Detailed documentation of experiments and results – Participation in lab and department meetingsCategoryLaboratory ID2023-1542 ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Postdoc
The Rankin Lab is seeking a Post-doctoral Fellow to study chromosome assembly and dynamics, how these events are controlled, and how corruption of these processes contributes to disease. Our lab forms part of the Program in Cell Cycle and Cancer Biology, which offers an excellent training environment in a state-of-the-art facility. We use a variety of experimental models, including cultured cells, biochemistry, extracts from frog eggs, and advanced microscopy to address problems of chromosome structure, replication, and inheritance. Experience directly related to this field is not necessary, but basic molecular biology skills are preferred. Applicants should demonstrate enthusiasm for the topic, willingness to learn, and the ability to work independently to develop their project(s), analyze experiments, and prepare manuscripts. Successful candidates will have good written and verbal communication skills and be willing to engage fully in lab and departmental activities. During their tenure in the Rankin lab, fellows will receive significant career development support. They can also expect to attend training courses as well as scientific conferences, where they can present their work and establish their presence in the research community.CategoryScientific ID2023-1545
Job LocationsUS-OK-Oklahoma City
Assistant/Associate/Full Professor
The Oklahoma Medical Research Foundation (https://omrf.org/) is seeking accomplished or upcoming investigators with expertise in aging as it relates to neuroinflammation and/or neurodegeneration to join the Aging and Metabolism Research Program. Successful candidates will be expected to maintain a vigorous independent research laboratory investigating mechanisms relevant to CNS aging associated with one or more of the following areas of special interest: inflammatory processes, circuits relevant to cognition/behavior, immune cell function, and bioenergetics. Successful candidates will receive an appointment at the Assistant, Associate, or Full Member level (Assistant, Associate, and Full Professor equivalents), dedicated research space, as well as a generous, multi-year start-up package with significant sustained salary and research support. The Aging and Metabolism Research Program is comprised of thirteen faculty members studying a variety of diseases related to the aging process, including neurological, metabolic, musculoskeletal, and cardiovascular disorders. OMRF supports an AAALAC accredited animal facility as well as state-of-the art core facilities for imaging, -omics technologies, tissue banking, and other facilitating resources. Additional information can be found at the Program’s website (http://omrf.org/programs/aging-and-metabolism-research-program/). Other attractive aspects include a generous startup package, institutional support for competitive salaries, comprehensive benefits, and a collegial work environment. OMRF investigators have no formal teaching obligations but can voluntarily participate in didactic activities on campus at The University of Oklahoma Health Sciences Center (OUHSC). Overall, OMRF is committed to creating an attractive position suitable for applicants with a proven track record or exceptional potential for high-quality funded research. OMRF is an independent, not-for-profit, biomedical research institute supporting five major interdisciplinary research programs. Our facilities are located adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) and the Oklahoma City VA Medical Center near downtown Oklahoma City. OMRF investigators are integral participants in OUHSC graduate programs and enjoy close scientific interactions with OUHSC and Oklahoma City VA faculty. EOE/AA Employer/Vet/DisabledCategoryScientific ID2023-1546 ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Research Technician II/Research Technician III
The Guthridge & James labs (james.omrf.org; Guthridge.omrf.org) are seeking a highly motivated and organized individual to contribute to projects designed to deconstruct the drivers of autoimmune disease at the molecular level in both preclinical and advanced disease states. Studies characterizing the immune cells and their responses against pathogens and autoreactive responses at the cellular and tissue levels using advanced single-cell multiomic phenotyping approaches, high-dimnensional biomarker profiling, and spatial multiomic techniques. Duties will include both basic and advanced cell and molecular biology techniques, such as Luminex and Olink biomarker assays in addition to ELISAs, Western blotting. Single cell techniques including multi-parameter flow cytometry, high-dimensional mass cytometry (CyTOF), imaging mass cytometry (Hyperion), and single cell transcriptomics, proteomics and repertoire using the latest 10X genomics platforms.CategoryLaboratory ID2023-1555 ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Full-Time or Part-Time Research Technician
The Ahamed lab is looking for a full-time or part-time Research Technician. Our laboratory studies mouse models of heart diseases with a particular focus on fibrosis. We utilize state-of-the-art techniques in genetics, molecular biology, cell biology, and biochemistry. The position involves breeding of our mouse colony, performing experiments utilizing a variety of techniques, analyzing data, contributing to management and contributing to laboratory management and oversight. Assists, as needed, with administering injections, medications, venipunctures, applying wound dressings, and with diagnostic procedures as directed by supervisor and/or consulting veterinarian. Identify, prepare and perform a variety of research experiments according to protocol. Projects and assignments are typically non-routine and variable in nature. Receive no instruction on routine work, but receive instructions on new work or special assignments. Collect and present data to Manager or Principal Investigator.CategoryLaboratory ID2023-1562 DepartmentCardiovascular Biology – Ahamed
Job LocationsUS-OK-Oklahoma City
Multiple Sclerosis Clinical Investigator
The Oklahoma Medical Research Foundation (OMRF) Multiple Sclerosis Center of Excellence is undergoing an exciting time of clinical and clinical research expansion through generous philanthropic support. We are recruiting two physician investigators with clinical research interests in investigator-initiated clinical trials, outcomes research, or other patient-oriented investigation to join our strong multi-disciplinary MS clinical care and research team. Building on strong clinical research infrastructure with longitudinal cohorts, a cadre of talented clinical coordinators/clinical research nurses, diverse aspects of clinical research informatics and a CAP-certified biorepository, we invite qualified candidates to apply for a clinical investigative position focusing on multiple sclerosis and related disorders. We are currently recruiting at the Assistant/Associate/Full Professor level. Talented candidates at all levels are encouraged to apply and will be considered. Successful applicants will: – Spearhead investigator-initiated, sponsor-led and/or NIH clinical trials – Provide comprehensive, optimal, science-driven multiple sclerosis patient care – Receive generous, multi-year start-up package with significant, sustained salary and research support – Collaborate with basic scientists interested in MS patient-oriented translational research – Interact closely with Oklahoma University Health Sciences Center faculty and participate in OUHSC house staff and medical training programs – Contribute toward and enjoy access to: – vibrant patient cohorts with associated patient care and clinical trials infrastructure – extensive autoimmune disease and control bio-specimen collections – outstanding OMRF and ACI Clinical and Research Core facilities Arthritis and Clinical Immunology investigators have access to a number of outstanding OMRF core facilities, including and state-of-the-art clinical facilities. Extensive autoimmune disease and control sample collections are also available. Pilot programs are also available through the Oklahoma Shared Clinical & Translational Resources funding streams, as well as through the Oklahoma Center for Advancement of Science and Technology. Our clinicians provide outpatient care with no in-patient admission or consulting requirements. OMRF (http://omrf.org) is an independent, not-for-profit biomedical research institute adjacent to the University of Oklahoma Health Sciences Center (OUHSC) campus in Oklahoma City. OMRF investigators enjoy close scientific interactions with OUHSC faculty and participate in OUHSC graduate programs. For more information about the OMRF MS Center of excellence, please visit: https://omrf.org/patient-studies/multiple-sclerosis/. For more information about the Arthritis and Clinical Immunology Research program, please visit: https://omrf.org/programs/arthritis-clinical-immunology-research-program/. CategoryScientific ID2023-1568 DepartmentArthritis & Clinical Immunology – Pardo ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Postdoc/Staff Scientist
A fulltime postdoc fellow/staff scientist position is available in Dr. Yoon laboratory in the Aging and Metabolism Reserach Program. Research in Yoon lab focus on discovery of new genetic/neurological diseases and their pathogenic mechanisms. We implement an experimental pipeline that leverages the combined power of clinical data, genomics analysis, and studies using Drosophila models and patient-derived stem cell models. Candidates with strong interest in neurological and genetic diseases and iPSC models are welcome to apply. We have discovered 5 novel Mendelian mitochondrial diseases including the Harel-Yoon syndrome and the Yoon-Bellen neurodevelopmental syndrome that bear my name (PMID: 27640307; PMID: 32004445; PMID: 33845882; PMID: 28017472; PMID: 34800363). We already established numerous disease models in human iPS cells. Hence, motivated postdoctoral fellows will have opportunities to explore exciting projects and publish high-impact papers.CategoryScientific ID2023-1599 DepartmentAging & Metabolism – Yoon ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Security Agent/Officer/Professional (Part-Time or Full-Time)
Are you passionate about creating a safe and secure environment? Join the Oklahoma Medical Research Foundation (OMRF) and play a crucial role in safeguarding our community. We are seeking dedicated individuals to join our Security Services Department with responsibilities spanning three key categories: Safety & Security • Conduct thorough foot patrols of Foundation buildings and grounds, ensuring the integrity of doors, windows, and gates. • Monitor, operate, and maintain various security systems/equipment, including access control, video surveillance, key tracking, and alert systems. • Swiftly evaluate and address suspicious persons, vehicles, or circumstances, taking appropriate action, including apprehension or expulsion of violators as needed. • Act as a first responder in security emergencies, coordinating responses to incidents such as fire alarms, bomb threats, medical emergencies, and more. • Stay updated on all security policies and undergo continuous training, including weapon qualification. Customer & Employee Experience • Serve as the first point of contact for visitors, patients, vendors, and employees, leaving a positive impression of the organization. • Build and maintain strong relationships within the organization and collaborate effectively with the University of Oklahoma Health Sciences Center (OUHSC) Police Department. • Monitor and manage the entrance and departure of individuals during regular business hours, special occasions, and events. Administrative • Run reports to analyze card activity, clearances, and other relevant data. • Submit thorough investigatory findings and produce well-documented reports as needed. • Prepare incident, recovered property, and daily log entries, ensuring accurate and comprehensive documentation.CategoryOther ID2023-1625 DepartmentSecurity Services
Job LocationsUS-OK-Oklahoma City
Research Technician – Biorepository
The Guthridge Lab is seeking a Research Technician for the Biorepository which supports our clinical and translational research investigators. Candidates should be highly organized, motivated and team oriented. Duties will include all repository activities related to receipt, processing, storage, maintenance and records management of human blood and tissue samples related to studies and clinical trials in a CAP (College of American Pathologists) certified facility. Individual will need to be comfortable working in cold temperatures with appropriate personal safety protections and working with human samples.CategoryLaboratory ID2023-1626 DepartmentArthritis & Clinical Immunology – Guthridge ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Postdoc – Reproductive Biology, Neuroscience, & Aging
The Ocañas Lab is interested in understanding how biological sex contributes to brain aging and Alzheimer’s disease. We are looking for a highly motivated postdoctoral research fellow to join the multidisciplinary Ocañas Laboratory within the Genes and Human Disease (GHD) Research Program at OMRF. The fellow will investigate how ovarian aging and altered endocrine signaling impacts neuroinflammation in the hippocampus. The successful candidate will employ a wide range of techniques including the generation of novel mouse models, single-cell transcriptomics, epigenomics, flow cytometry, histology & pathological assessments, and a variety of other cellular & molecular biology techniques. The candidate will present their data regularly in laboratory meetings, local seminars and symposiums, and will have opportunities to present their work at national conferences. A requirement of the position is that the candidate must demonstrate ethical behavior at all times, a high-level of scientific rigor, and must be detail-oriented and able to work independently and as part of a team. The Ocañas Laboratory and GHD Research Program welcome applicants from diverse backgrounds that thrive in a highly collaborative and supportive environment. We are strongly committed to providing individualized mentoring and assistance with career advancement through the implementation of a postdoctoral mentoring committee. The GHD Research Program, which currently consists of 7 highly collaborative investigators, provides an exceptional training environment in genomic techniques and bioinformatics. The OMRF Postdoctoral Association offers additional training opportunities related to grant writing, presentation skills, and career development. The vibrant and highly collaborative environment within OMRF has resulted in the foundation being named the top large employer in the state of Oklahoma three times in the last five years.CategoryScientific ID2023-1628 DepartmentGenes & Human Disease – Ocañas ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Postdoc
The Srinivasan Lab at Oklahoma Medical Research Foundation (OMRF) is recruiting motivated researchers to study lymphatic vascular development and disease and heart valve development and disease. We use biochemical, cell biological and transgenic technologies to dissect the roles of transcription factors and signaling molecules that regulate lymphatic vascular development and disease. Please check our latest publications: Cha et al (2016) Genes Dev. (cover image) June 16; 30: 1-16; Cha et al (2018) Cell Reports. (cover image) October 16; 25(3):571-584; Mahamud et al (2019) Development. November 5;146(21):dev184218; Geng et al (2020) JCI Insight. (cover image) July 23;5(14):e137652; Chen et al (2020) Development. (cover image) Dec 7;147(23):dev192351; Cha et al (2020) Development. (cover image) Dec 13;147(23):dev195453 and Ho et al (2023)., Circulation research. (cover image and editorial comment), Sep;133(6):463-480. The ideal candidate will be enthusiastic about challenging projects and will have experience with Molecular Biology, Biochemistry or Immunology. Experience with mouse models is a plus. Additional information about OMRF can be found at http://omrf.org. Please check the Srinivasan lab website for more information about our research: https://srinivasan.omrf.org/.CategoryScientific ID2023-1637 DepartmentCardiovascular Biology – Srinivasan ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Purchasing Agent
• Reviews requisitions to verify accuracy, terminology, specifications. Approves requisitions for conversion to Purchase Orders. • Confers with vendors to obtain product or service information such as price, availability, and delivery schedule. • Estimates values according to knowledge of market price. • Prepares bid requests when required. • Reviews bid proposals and negotiates contracts within budgetary limitations and to scope of authority. • Maintains procurement records such as items or services purchased, costs, delivery, product quality or performance, and inventories. • Troubleshoots with users, vendors, and others regarding defective or unacceptable goods or services and determines source of trouble and takes corrective action. • Assists and coordinates with the Accounting Department the processing of completed purchase order payments. • Approves invoices for payment. • Expedites delivery of goods/services to users. • Processes and ships returned goods to vendor and ensures proper credits are received. • Consults catalogs and interviews suppliers to obtain prices and specifications. • Prepares purchase orders and sends copies to supplier when a hard copy is required. • Compares prices, specifications, and delivery dates to provide best value for end users. • Verifies invoices from suppliers with bids/quotes and purchase orders and approves payment. • Performs other duties as assigned by the supervisor.CategoryAdministrative ID2023-1638 DepartmentPurchasing ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Fleming Scholar Summer Research Internship
Fleming Scholars work for 8 weeks in the summer (June 3 – July 26, 2024) in state-of-the-art biomedical research laboratories on individual projects and are supervised by senior members of the OMRF scientific staff. Scholars attend weekly seminars as well as occasional social events as a group. On the final day of the program, scholars give formal scientific seminars outlining the findings of their projects. Each scholar also writes an abstract summarizing their summer project. OMRF will provide dormitory housing free of charge to all students who live outside of the OKC Metro area (defined as a 40-mile radius from OMRF).
Research Technician
The Bieniasz Lab (Aging & Metabolism Research Program) is seeking highly motivated Research Technician candidates with high focus on professional growth and career advancement. The Research Technician will contribute to projects exploring the mechanisms of ovarian cancer progression, metastasis and chemotherapy resistance. We are investigating various aspects of ovarian cancer development, progression and response to innovative therapies as well as projects studying ovarian aging. To study ovarian cancer, we use in vitro mouse and human ovarian cancer cell lines and in vivo mouse models such as genetically engineered mouse models (GEMMs) and patient-derived xenograft (PDX) models of ovarian cancer. The Research Technician will be responsible for performing a wide variety of projects including: • in vitro cell culture • mouse colony management • maintaining cell lines and tumor tissues • mouse procedures and surgeries • advanced tumor monitoring and imaging • preclinical drug efficacy studies • in vivo data management and analysis • performing various biochemical and molecular assays We are seeking individuals who will manage and conduct research projects and present scientific/technical information both formally and informally. The Research Technician position is eligible for career advancement if performance goals are met.CategoryLaboratory ID2023-1644 DepartmentAging & Metabolism – Bieniasz
Job LocationsUS-OK-Oklahoma City
Staff Scientist
The Bieniasz Lab (Aging & Metabolism Research Program) is seeking a self-motivated, creative biologist to study changes in aging ovaries that predispose to ovarian cancer development. The successful candidate will perform various in vitro assays to study ovarian cancer phenotype, and in vivo studies using genetically engineered mouse models (GEMMs), and patient-derived xenograft (PDXs) models to study ovarian cancer development, progression, spreading and response to novel therapies. She/he will be expected to present their data in lab meeting and present their work in seminars and poster presentations as appropriate. The candidate will be expected to perform data analysis, prepare manuscripts, contribute to grant writing, and communicate effectively both orally and in writing. The candidate will be expected to troubleshoot scientific problems and modify experimental protocols when needed. She/he will also participate in various lab management responsibilities. The candidate will be expected to work independently with a high degree of skill under the guidance of the lab supervisor.CategoryScientific ID2023-1645 DepartmentAging & Metabolism – Bieniasz
Job LocationsUS-OK-Oklahoma City
OMRF OKC-VA LU Biomedical Research Scholars
Scholars work for 8 weeks in the summer (June 3 – July 26, 2024) in state-of-the-art biomedical research laboratories on individual projects and are supervised by senior members of the OMRF scientific staff. Scholars attend weekly seminars as well as occasional social events as a group. On the final day of the program, scholars give formal scientific seminars outlining the findings of their projects. Each scholar also writes a scientific paper summarizing their summer project. All complete application packets must be submitted or postmarked by February 9, 2024.CategoryLaboratory ID2023-1647 ClassificationTemporary
Job LocationsUS-OK-Oklahoma City
Research Technician – Alzheimer’s Disease
The Rice Lab is seeking a Research Technician to conduct research in cellular and molecular mechanisms of Alzheimer’s disease and normal brain function using mouse models. Responsibilities will include, but are not limited to: – Managing mouse colony (updating strain database, setting up breeders, and genotyping by PCR) – Euthanizing mice and dissecting brain tissue – Sectioning, immunostaining, and imaging brain tissue – Participating in lab and departmental meetingsCategoryLaboratory ID2023-1648 DepartmentAging & Metabolism (A&M)
Job LocationsUS-OK-Oklahoma City
Animal Care Technician
1. Performs basic animal care functions including daily health observations and cage changing. 2. Performs routine medical treatments under the direction of the supervisor and veterinarian. 3. Maintains a clean and safe working environment 4. Clean and sanitize assigned areas of facility per department SOP’s. 5. Maintain quality control records. 6. Performs, as directed, safety compliance and uses Personal Protective Equipment (PPE), as needed. 7. Assist with monitoring facility environment, notify supervisor of any problems detected. 8. Carry out all duties in compliance with standards of oversight bodies (AAALAC, PHS, etc.) and department SOP’s. 9. Maintains positive working relationships as a team player through problem solving issues, speaking positively about others, listening attentively and observing the Confidentiality of research needs. 10. Performs all other duties as assigned.CategoryLaboratory ID2023-1655
Job LocationsUS-OK-Oklahoma City
Administrative Assistant – Genes & Human Disease Research Program
Provide assistance and organization to multiple Principal Investigators (PIs) and maintain a professional office environment. Manage all aspects of grant submissions. Assist with preparation and submission of NIH and foundation grant applications, including budget assembly, copy editing, graphic preparation, on-line submissions and review that application meets the federal requirements. Assist in drafting or editing letters, IRB applications and other regulatory documents. Assist with budget preparation. Organize and maintain records of grant effort distribution and monthly accounting reports. Monitor and notify PIs of various deadlines well in advance of due date especially for grant reporting and renewal, membership renewal, abstract, and meeting deadlines. Manage all calendars. Manage all travel arrangements and reimbursements then coordinate with accounting as needed. Assist organizing PI offices. Assist in purchasing office equipment and supplies. Update and organize CVs and Biosketches in shared folder. Assist organizing bibliographies and paper collections. Maintain instructions for journal submissions. Track and carry out public domain submissions. Answer phones, take messages and convey them to PIs. Provide consistent feedback to PIs regarding completion of major tasks, office operations and any issues. Initiate and arrange monthly meetings with PIs to review and coordinate workloads, deadlines, etc.CategoryAdministrative ID2023-1660 DepartmentGenes & Human Disease – Gaffney
Job LocationsUS-OK-Oklahoma City
Postdoc – Biomechanics & Vascular Dynamics
The laboratory of Dr. Brian Coon in the Cardiovascular Biology Research Program at the Oklahoma Medical Research Foundation (OMRF) is seeking postdoctoral scientists. The Coon lab studies the physiological relationship between vascular biomechanics and homeostasis, and how the disruption of these circuits contributes to vascular diseases. We are multidisciplinary and welcome applicants with diverse backgrounds. After an initial selection period, applicants will be invited to discuss projects that leverage their scientific interests and technical strengths to address critical questions in vascular biology. Examples of our current projects include the study of – novel mouse genetic models of human diseases, genetic and biochemical drivers of vascular remodeling, crosstalk between mechanotransduction and metabolism pathways, and cell state transitions. OMRF is an independent, nonprofit biomedical research institute. The innovative basic and translational research at OMRF covers critical areas such as cardiovascular disease, autoimmune disease, aging, and cancer. OMRF has made The Scientist magazine’s annual list of the “Best Places to Work for Postdocs” for many years. The institute offers postdoctoral fellows an exceptional research and training environment with state-of-the-art facilities and outstanding core technology laboratories including imaging, next-gen and spatial sequencing, and clinical genomics. Throughout their tenure, postdocs will be offered scientific and career development support through both Dr. Coon and institutional programs. This may include a faculty mentoring committee, grants and manuscript writing, and travel awards to attend international meetings and workshops.CategoryScientific ID2023-1665 DepartmentCardiovascular Biology – Coon ClassificationOn-going
Job LocationsUS-OK-Oklahoma City
Laboratory/Research Technician
The Zhao Lab is looking for a Laboratory/Research Technician. This position provides an excellent opportunity for an individual who wants to begin a career in science and/or medicine. The laboratory/research technician is expected to perform routine laboratory procedures according to standardized protocols and report results. The individual receives detailed instructions on assignments and regular supervision. Research projects in the Zhao lab are centered around the regulatory mechanisms for T cell development and functions important for therapeutics against autoimmune diseases, infectious diseases, and cancers. The individual will receive training in state-of-the-art immunology, genetics, molecular biology, and developmental biology techniques. The individual will have opportunities to work with a team on significant projects or lead independent projects.CategoryLaboratory ID2024-1666 DepartmentArthritis & Clinical Immunology – Zhao
Job LocationsUS-OK-Oklahoma City
Postdoc/Assistant Staff Scientist
The laboratory of Dr. Meng Zhao in the Arthritis and Clinical Immunology Research Program at the Oklahoma Medical Research Foundation (OMRF) is seeking a highly motivated Postdoc/Assistant Staff Scientist to investigate the metabolic regulation of T cells in the pathogenesis of human diseases. The Postdoc’s project focuses on understanding the mechanistic interaction between metabolic remodeling and immune functions during the development of autoimmune, infectious diseases or cancer. The Postdoc will work with cutting edge resources including spectral flowcytometry, high resolution microscopy, novel genetically modified mouse models, metabolomic analysis, and single cell transcriptomic analysis. OMRF has made The Scientist magazine’s annual list of the “Best Places to Work for Postdocs” for many years. Arthritis and Clinical Immunology Program is the home base for one of only 10 Autoimmune Centers of Excellence (ACE) in the U.S. Apart from the close mentorship from Dr. Zhao, the postdoc will benefit from departmental journal clubs, seminar series, and the expertise from diverse approaches in the program and the institute. Moreover, OMRF postdoc training committee and Postdoc association will provide additional resource and advice. Our collective goal is to help make the postdoc training experience at OMRF productive and successful. Selected publications Zhao M*#, Quintana A*, Zhang C*, Andreyev AY*, Kiosses W, Kuwana T, Murphy A, Hogan PG#, Kronenberg M#. Calcium signals regulate the functional differentiation of thymic iNKT cells. EMBO J. 2021 Aug 16;40(16):e107901, PMID: 34169542 (* co-first authors, # co-corresponding authors) Zhao M*, Svensson M*, Venken K, Sethi A, Engel I, Day JD, Elewaut D, Bottini N, Kronenberg M. Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70. Nat. Communications. 2018 Jul 6. 9:262 (* co-first author) PMCID: PMC6035278 Chandra S*, Zhao M*, Budelsky A, de Mingo Pulido A, Day J, Fu Z, Siegel L, Smith D, Kronenberg M. A new mouse strain for the analysis of invariant NKT cell function. Nat Immunology. 2015 Aug;16(8):799-800. (* co-first author) PMCID: PMC4711267CategoryScientific ID2024-1667 DepartmentArthritis & Clinical Immunology – Zhao
Job LocationsUS-OK-Oklahoma City
Research Technician
The Miller Lab is currently hiring for a Research Technician who will design, perform and analyze complex research experiments. Organizes, interprets, and communicates data to supervisor and co-workers. Modifies protocols to improve processes. Documents work appropriately. Troubleshoots problems in lab. May provide guidance to research staff, graduate students, and post docs. Collaborates, builds constructive relationships, and effectively communicates with other members of the lab. Works independently, but seeks assistance when needed. Operates highly specialized equipment requiring moderate to high degree of skill. Expected to perform more advanced techniques after appropriate training. Ability to work well with others is essential.CategoryLaboratory ID2024-1668 DepartmentAging & Metabolism – Miller
Job LocationsUS-OK-Oklahoma City
Postdoc – Aging Biology, Epigenetics
The Freeman Lab is seeking to hire a Postdoc to work on NIH and VA aging research projects that examine the role of epigenetic changes in the CNS and other organ systems across ages, between sexes, and with anti-aging treatments. The project utilizes transgenic mice with cell-type specific labeling that allows for advanced sequencing and bioinformatic techniques to examine genome regulation at the single cell-type and single-cell level. These projects also integrate animal behavior, biochemical assessments, and state-of-the-art cytometry and imaging. The lab environments is highly supportive of learning new including techniques for molecular biology, proteomics, epigenetics, and bioinformatics. The ideal candidate will be innovative, collaborative, and highly motivated who can work independently but also with other investigators of varied training experience. The environment within the Aging Research Community at OMRF/OKC VAMC/OUHSC is rich with opportunities for students and postdocs. Aging research (Geroscience) is a cross-institution thematic priority and the program has grown dramatically in recent years through the addition of new faculty, the Oklahoma Nathan Shock Center of Excellence in the Basic Biology of Aging and the Geroscience Training Program (T32). CategoryScientific ID2024-1669 DepartmentGenes & Human Disease – Freeman ClassificationTemporary
Job LocationsUS-OK-Oklahoma City
Facilities Assistant/Handyperson
Assist Facility Services and Scientific Instruments Services teams including but not limited to: – cleaning up and organizing mechanical areas and other work areas – assembling and moving furniture and equipment – assisting with renovations – assisting skilled tradespeople with various projects, performing some maintenance, minor carpentry, and light repairs, perform handyperson duties such as hanging pictures, shelving, and minor repairs – assisting and/or covering leave as needed on dock and mailroom receiving and delivering packages – assisting with event set-up, cleanup and other preparations – assisting security during events and/or on special occasions – assisting with inclement weather and/or emergency tasks such as snow removal – picking up trash and maintaining grounds around the dock as neededCategoryOther ID2024-1670 DepartmentFacility Services
Job LocationsUS-OK-Oklahoma City
Staff Scientist – Proteomics
The Miller Lab is seeking a qualified candidate to fill a position of a staff scientist interested in proteomics and data science. The Miller Lab is based in the Aging & Metabolism Research Program and studies proteostatic regulation in aging skeletal muscle and other tissues with a particular focus on mitochondria. The Miller Lab collaborates with many investigators throughout the country on studies using stable isotopic labeling. The lab also is a core in the National Institute on Aging (NIA)-funded Oklahoma Nathan Shock Center for the basic biology of aging. Primary responsibilities include sample preparation, data analysis, coding, and