The Scripps Research Institute in the United States invites application for vacant Postdoc and Academic Positions, a nonprofit American medical research facility that focuses on research and education in the biomedical sciences.
INTERN RESEARCH – Zwick Lab
Jul 21, 2025
Job Category: Internships
Requisition Number: INTER004186
Schedule: Part TimeCA Campus
San Diego, CA, USA
Assist with basic laboratory maintenance, including glassware washing, autoclaving, and preparing media and solutions. Support experimental procedures assigned by our experienced staff and contribute to ongoing research projects.
SENIOR LAB ANIMAL VETERINARIAN
Jul 21, 2025
Job Category: Animal Resources
Requisition Number: SENIO004173
Schedule: Full Time
Job Location Type: On-siteCA Campus
San Diego, CA, USA
Scripps Research is looking to fill the role of Senior Laboratory Animal Veterinarian for the Department of Animal Resources. We are seeking a mid-career Laboratory Animal Veterinarian to lead a team of four Veterinary Technicians in caring for multiple species (mouse, rat, hamster, rabbit) over five facilities. The ideal candidate will assume both formal and informal leadership roles, to include managing direct reports and voting membership on the IACUC and IBC. They will be expected to integrate effectively with a variety of scientists and stakeholders and excel in facilitating cross-functional activities within and between departments and labs. Furthermore, this exciting opportunity offers compelling prospects for career growth.
RESEARCH ASSISTANT II-Immuno-Oncology
Jul 18, 2025
Job Category: Research Staff
Requisition Number: RESEA004189
Schedule: Full Time
Job Location Type: On-siteCA Campus
San Diego, CA, USA
ABOUT US: Scripps Research is ranked the most influential institution in the world for its impact on innovation. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Scientists in the institute’s five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Ca
PEOPLE OPERATIONS ANALYST II
Jul 18, 2025
Job Category: Human Resources
Requisition Number: PEOPL004187
Schedule: Full Time
Job Location Type: On-siteCA Campus
San Diego, CA, USA
The People Operations Analyst II will play a strategic and hands-on role in optimizing and supporting the UKG Human Resources Information System at Scripps Research. This mid-level position is ideal for a professional with 5+ years of HRIS experience who excels at turning complexity into clarity, improving systems, and enabling data-driven decision-making. You will serve as a key liaison between HR, Payroll, and IT, ensuring that our HR technology supports the evolving needs of the organization
POSTDOCTORAL ASSOCIATE – Liu Lab – Immunology and Microbiology
Jul 15, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD004172
Schedule: Full TimeCA Campus
San Diego, CA, USA
Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of five years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges.
POSTDOCTORAL ASSOCIATE – Andersen Lab
Jul 15, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD004171
Schedule: Full TimeCA Campus
San Diego, CA, USA
The Andersen Lab is looking for a postdoc with experience in pathogen discovery and virology to help out with our highly collaborative work on H5N1, SARS-CoV-2, and Mpox, and lead new projects across our range of viruses and research interests. This position is part of our larger initiatives, including Modjadji (https://modjadji.info/), PREVENT (https://preventcohorts.org), SEARCH (https://searchcovid.info/), Outbreak.info (https://outbreak.info/), and the Center for Viral Systems Biology (https://cvisb.org/).
RESEARCH ASSISTANT I-Zhu Lab
Jul 9, 2025
Job Category: Research Staff
Requisition Number: RESEA003878
Schedule: Full Time
Job Location Type: On-siteCA Campus
San Diego, CA, USA
Scripps Research is ranked the most influential institution in the world for its impact on innovation. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve well-being. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Scientists in the institute’s five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr to merge foundational studies in biology, chemistry and computer science with translational science to produce pioneering drugs and
MAINTENANCE MECHANIC II
Jul 9, 2025
Job Category: Facilities Services
Requisition Number: MAINT004167
Schedule: Full Time
Job Location Type: On-siteCA Campus
San Diego, CA, USA
The Maintenance Mechanic II, reporting to the Facilities Supervisor, performs maintenance, installation, and repairs of a wide variety of equipment and buildings in support of the daily operations of the Scripps Research facilities, labs, offices, equipment, and grounds.
RESEARCH ASSISTANT III – JIN LAB
Jul 3, 2025
Job Category: Research Staff
Requisition Number: RESEA003274
Schedule: Full TimeCA-ALL
California, USA
ABOUT US: Scripps Research is ranked the most influential institution in the world for its impact on innovation. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Scientists in the institute’s five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr to merge foundational studies in biology, chemistry and computer science with translational science to produce pioneering drugs and advance
ANIMAL TECHNICIAN II
Jul 1, 2025
Job Category: Animal Resources
Requisition Number: ANIMA003872
Schedule: Full TimeCA Campus
San Diego, CA, USA
We have an exciting opportunity for an Animal Technician II supporting the Department of Animal Resources at Scripps Research in La Jolla, California, home to some of the world’s most renowned scientists. This is a great opportunity for someone who is excited to share great science with the community. The Animal Technician II is responsible for the daily care of research animals including feeding, cage washing, maintaining a clean environment, and monitoring the overall health of the animals. May perform routine procedures and post-operative care as directed.
RESEARCH ASSISTANT I – Infectious Disease (Calibr)
Jun 25, 2025
Job Category: Scientific Staff
Requisition Number: RESEA004142
Schedule: Full TimeCA Campus
San Diego, CA, USA
Scripps Research is ranked the most influential institution in the world for its impact on innovation. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Scientists in the institute’s five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr to merge foundational studies in biology, chemistry and computer science with translational science to produce pioneering drugs and
LICENSED STAFF COUNSELOR (part-time) – FLORIDA
Jun 21, 2025
Job Category: Counseling Services
Requisition Number: LICEN003522
Schedule: Full Time
Job Location Type: On-siteFL-ALL
Jupiter, FL, USA
Provides counseling, assessment and consultation to students as well as scientific and support staff on the California campus. Provides in-house presentations and crisis debriefing to the Florida campus community.
RESEARCH ASSISTANT, SENIOR- Mass Spectrometry & Proteomics – Yates Lab
Jun 3, 2025
Job Category: Research Staff
Requisition Number: RESEA004100
Schedule: Full TimeCA Campus
San Diego, CA, USA
ABOUT US: Scripps Research is ranked the most influential institution in the world for its impact on innovation. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Scientists in the institute’s five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr to merge foundational studies in biology, chemistry and computer science with translational science to produce pioneering drugs and advance
POSTDOCTORAL ASSOCIATE – Kennedy Lab – Neuroscience
May 1, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD003731
Schedule: Full Time
Job Location Type: On-siteCA Campus
San Diego, CA, USA
The Kennedy lab is recruiting for multiple funded postdoctoral positions in theoretical and computational neuroscience. Ongoing projects in the lab span topics in: Reservoir computing with heterogeneous cell types Reinforcement learning/control theory analysis of complex behavior Neuromechanical whole-organism modeling Imitation learning/generative modeling of mouse social interactions Joint analysis/modeling of effects of internal states on neural + vocalization + behavior data
ANIMAL TECHNICIAN I
Apr 12, 2025
Job Category: Animal Resources
Requisition Number: ANIMA003871
Schedule: Full TimeCA Campus
San Diego, CA, USA
We have an exciting opportunity for an Animal Technician I supporting the Department of Animal Resources at Scripps Research in La Jolla, California, home to some of the world’s most renowned scientists. This is a great opportunity for someone who is excited to share great science with the community. This entry level position is responsible for the daily care of research animals including feeding, cage washing, maintaining a clean environment and monitoring the overall health of the animals.
ASSOCIATE CLINICAL TRIAL MANAGER
Mar 13, 2025
Job Category: Research Administration
Requisition Number: ASSOC003720
Schedule: Full TimeCA Campus
San Diego, CA, USA
The Associate Clinical Trial Manager supports the internal Calibr-Skaggs Clinical team, clinical site teams and CRO/vendor partners in execution of early-phase clinical trials across multiple therapeutic areas. Focus on immuno-oncology and a wide range of programs covering neurodegeneration, metabolic disorders, autoimmunity, and others. Assists in the execution of complex clinical programs, participates in the design and planning of clinical studies, and delivers successful operational outcomes across multiple Phase 1 and 2 clinical trials. The Clinical Trial Manager will apply their excellent operational capabilities as the main driver for project delivery within timelines and budget in accordance with the protocol while ensuring compliance with ethical and regulatory requirements.
RESEARCH TECHNICIAN – Jin Lab
Mar 12, 2025
Job Category: Research Staff
Requisition Number: RESEA003838
Schedule: Full TimeCA Campus
San Diego, CA, USA
The Jin Lab is seeking a skilled research technician to contribute to the development of innovative genomic technologies, focusing on their application in studying brain development. Energetic, bright, and highly motivated candidates with backgrounds in chemistry, biology, neuroscience, biochemistry, molecular biology, genetics, bioengineering, or physiology are especially encouraged to apply. This role involves direct collaboration with the principal investigator, contributing to publications, and gaining valuable bench-side experience. Additionally, the successful candidate will oversee lab operations, ensuring space allocation, equipment maintenance, and safety protocols are upheld, while handling additional responsibilities as needed.
RESEARCH TECHNICIAN – Ran Lab
Mar 12, 2025
Job Category: Research Staff
Requisition Number: RESEA003854
Schedule: Full TimeCA Campus
San Diego, CA, USA
The Department of Neuroscience at Scripps Research has open positions in the new lab of Dr. Chen Ran. We are interested in understanding, on the cellular, circuit, and systems levels, the neural basis of interoception, i.e., how the brain receives signals from the visceral organs within the body to generate our internal senses. We seek to unravel how the nervous system detects mechanical, chemical, and thermal stimuli from the periphery to synthesize our internal sensations, including satiety, hunger, nausea, hypoxia, and visceral pain. The research technician will perform a variety of routine scientific tasks; may prepare test specimens; set up and operate standard lab equipment of moderate complexity.
RESEARCH ASSISTANT I- Wu Lab
Feb 28, 2025
Job Category: Research Staff
Requisition Number: RESEA003817
Schedule: Full TimeCA Campus
San Diego, CA, USA
Will participate in immunology oncology research. Day-to-day job duties include maintaining flow cytometer, mouse husbandry, assisting molecule and cell biology experiments, participating in vivo murine tumor model studies. Will work Under general supervision, independently and in collaboration with others, perform research for projects; may provide interpretation and initial analysis of results; may investigate, troubleshoot and modify methods and procedures; may assist in designing experiments; perform other related duties, tasks and responsibilities as required or assigned.
POSTDOCTORAL ASSOCIATE – Zhang Lab – Molecular and Cellular Biology
Feb 24, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD003638
Schedule: Full TimeCA Campus
San Diego, CA, USA
The Zhang Lab at Scripps Research is seeking a highly motivated Postdoctoral Associate to develop innovative imaging tools aimed at advancing our understanding of tissue function across spatial and temporal scales.
POSTDOCTORAL ASSOCIATE – Chanda Lab – Immunology and Microbiology
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD001260
Schedule: Full TimeCA Campus
San Diego, CA, USA
A Postdoctoral Associate position is immediately available in the Immunology and Microbiology Department in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program focused on using a systems-level understanding of innate immunity, immunology, and virus-host interactions. The successful candidate will join a team investigating mechanisms of virus-host interactions, with a focus on utilizing chemical biology and chemoproteomics tools to identify novel host-pathogen interactions that underlie viral infection and to develop novel therapeutic strategies to facilitate pandemic preparedness.
POSTDOCTORAL ASSOCIATE (Electrophysiology) – Immunology and Microbiology – Sanna Lab
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD001255
Schedule: Full TimeCA Campus
San Diego, CA, USA
A Postdoctoral Associate position is available for a motivated individual to join a dynamic multidisciplinary research team at The Scripps Research Institute to study the neurobiology of substance abuse and neuroAIDS with in vivo, biochemical and genomic strategies including gene expression anlaysis by single cell RNA-Sequencing, electrophysiology and the establishment of neuronal cell types from induced pluripotent stem cells and fibroblasts.
POSTDOCTORAL ASSOCIATE – Immunology and Microbiology – Sanna Lab
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD002628
Schedule: Full TimeCA Campus
San Diego, CA, USA
Three Postdoctoral Associate positions are available for motivated individuals to join a dynamic multidisciplinary research team at Scripps Research to study neuroimmunological and neuroinflammatory aspects of alcohol and drug abuse, neuroAIDS, Alzheimer’s, and their detrimental interactions, with genomic and single cell RNA-Sequencing.
POSTDOCTORAL ASSOCIATE – CHEMISTRY – ERB LAB
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD001252
Schedule: Full TimeCA Campus
San Diego, CA, USA
Multiple fully funded positions for post-doctoral fellows are currently available in the Erb laboratory (Department of Chemistry, The Scripps Research Institute, La Jolla, CA). Our chemical biology group uses discovery chemistry, CRISPR/Cas9-based functional genetic screens, and advanced transcriptional genomics approaches to discover and study drug-like small molecules that therapeutically modulate chromatin regulation and mRNA transcription (see: https://www.erblab.scripps.edu/publications). We are seeking to hire multiple post-doctoral fellows to lead projects in ligand discovery, chromatin regulation, and cancer biology.
POSTDOCTORAL ASSOCIATE – Badran Lab – Chemistry
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD001248
Schedule: Full TimeCA Campus
San Diego, CA, USA
Dr. Ahmed H. Badran’s laboratory at Scripps Research seeks to hire 3-4 highly motivated Postdoctoral Associates. The Badran Lab aims to address technical shortcomings in conserved cellular processes through innovative synthetic/chemical biology, directed evolution, genome editing and bioengineering approaches.
POSTDOCTORAL ASSOCIATE – Neuroscience – Lippi Lab
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD001323
Schedule: Full TimeCA Campus
San Diego, CA, USA
The Lippi lab at Scripps Research seeks a Postdoctoral Associate as part of a growing team of investigators studying how a class of non-coding RNAs, called microRNAs, instructs brain development. We have developed molecular tools to map and manipulate microRNA-target interactions in specific cell types of the brain. We are now recruiting researchers that want to apply these tools to understand microRNAs mechanisms establishing neuronal identity and wiring neural circuits.
POSTDOCTORAL ASSOCIATE – Briney Lab – Immunology and Microbiology
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD001487
Schedule: Full TimeCA Campus
San Diego, CA, USA
The Briney Lab is seeking a Postdoctoral Associate to join us in the Department of Immunology and Microbiology at Scripps Research. We use a combination of advanced single cell multi-omics techniques and sophisticated computational tools to deeply explore the antibody response to emerging infectious diseases. We are looking for a highly motivated individual who will contribute to antibody discovery projects against a variety of viral targets, including Lassa, Ebola, HIV, SARS-CoV-2, influenza and others.
POSTDOCTORAL ASSOCIATE – Ran Lab – Neuroscience
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD002616
Schedule: Full TimeCA Campus
San Diego, CA, USA
The Department of Neuroscience at Scripps Research has open Postdoctoral Associate positions in the new, well-funded lab of Dr. Chen Ran. We are interested in understanding, on the cellular, circuit, and systems levels, the neural basis of interoception, i.e., how the brain receives signals from the visceral organs within the body to generate our internal senses. Combining state-of-the-art in vivo functional imaging, electrophysiological recordings, mouse genetics, neuronal activity manipulation, animal behavior, and computational approaches, our lab seeks to unravel how the nervous system detects mechanical, chemical, and thermal stimuli from the periphery to synthesize our internal sensations, including satiety, hunger, nausea, hypoxia, and visceral pain.
POSTDOCTORAL ASSOCIATE – Sanner Lab – Integrative Structural and Computational Biology
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD003348
Schedule: Full TimeCA Campus
San Diego, CA, USA
The Sanner lab is part of the Center for Computational Structural Biology (CCSB) at Scripps where we develop cutting edge software for modeling,analyzing, and visualizing molecular interactions which we make available to the worldwide research community. Under the AutoDock Suite umbrella of automated docking software tools we have recently developed AutoDock CrankPep, a docking engine specifically designed for ab-initio docking of fully flexible peptides.We seek a highly motivated and talented individual interested in method development in automated docking and their application to biomedically relevant drug discovery efforts. Candidate will join a lab integrated in the highly collaborative CCSB center and continue developing the ADCP software and apply it to biomedically relevant targets.
POSTDOCTORAL ASSOCIATE – Gallay Lab – Immunology and Microbiology
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD003493
Schedule: Full TimeCA Campus
San Diego, CA, USA
The Dr. Gallay lab in the Immunology and Microbiology department is seeking a Postdoctoral Associate researcher to discover new therapeutic candidates that can effectively combat SARS-CoV-2 infection and COVID-19 in both mice and in vitro models.
POSTDOCTORAL ASSOCIATE – Srinivasan Lab – Neuroscience
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD003612
Schedule: Full Time
Job Location Type: On-siteCA Campus
San Diego, CA, USA
Scripps Research is seeking a motivated postdoctoral associate in the Dr. Srinivasan lab to work in the area of neural the gut-brain axis and neuroendocrine biology of lipid metabolism.
POSTDOCTORAL ASSOCIATE (Computational) – Immunology and Microbiology – Sanna Lab
Jan 31, 2025
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD003649
Schedule: Full TimeCA Campus
San Diego, CA, USA
Scripps Research is seeking a qualified candidate for a Postdoctoral Associate position in Dr. Pietro Paolo Sanna’s laboratory. Candidates should have outstanding scientific credentials, including publications in journals relevant to the field of systems biology, and conference presentations. Candidates possessing a strong background in computer science, machine learning, physics, mathematics combined with a good understanding of genomics and molecular biology will be preferred. The optimal candidate will have significant experience and publications in network-based biology, including the reverse engineering and/or use of regulatory/signaling networks to elucidate the molecular determinants of specific cellular phenotypes and associated mechanisms for follow-up experimental validation.
RESEARCH TECHNICIAN – Badran Lab
Jan 10, 2025
Job Category: Research Staff
Requisition Number: RESEA003560
Schedule: Full TimeCA Campus
San Diego, CA, USA
Dr. Ahmed H. Badran’s Laboratory at The Scripps Research Institute seeks to hire TWO highly motivated full-time Research Technicians. The Badran Lab is interested in applying synthetic and chemical biology principles to create expanded genetic codes, improve biosynthetic carbon fixation strategies, and develop novel antimicrobial therapeutics. The research technicians would lead efforts towards the creation of robust genetic circuits and reporters for cellular bioactivities, with a focus on importing heterologous machinery in the laboratory workhorse bacterium Escherichia coli. This position will also include optimizing existing techniques and developing improved methods for troubleshooting of synthetic designs.
STAFF SCIENTIST – JIN LAB
Dec 6, 2024
Job Category: Scientific Staff
Requisition Number: STAFF003676
Schedule: Full Time
Job Location Type: On-siteCA Campus
San Diego, CA, USA
The Jin Lab at Scripps Research is seeking a highly motivated and talented Staff Scientist. The ideal candidate will possess outstanding scientific credentials, including publications in high-impact journals relevant to genomics, imaging, and cell biology. The Staff Scientist will work with scientific project leads and trainees in carrying out day-to-day research across a range of genomics projects. They will oversee and direct the development of novel genomic assays involving single cell and spatial genomic experiments and state-of-the-art imaging analysis. The Staff Scientist will utilize project management skills to prioritize and manage consortium collaborations, coordinate within and across labs in the consortium, and ensure scientific progression.
STAFF SCIENTIST (Computational) -Sanna Lab
Nov 8, 2024
Job Category: Scientific Staff
Requisition Number: STAFF001699
Schedule: Full TimeCA Campus
San Diego, CA, USA
The Scripps Research Institute is seeking a qualified candidate for a Staff Scientist (computational) position in Dr. Pietro Paolo Sanna’s laboratory.
RESEARCH ASSISTANT I – Badran Lab
Oct 22, 2024
Job Category: Research Staff
Requisition Number: RESEA003600
Schedule: Full Time
Job Location Type: On-siteCA Campus
San Diego, CA, USA
Scripps Research is ranked the most influential institution in the world for its impact on innovation. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Scientists in the institute’s five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr to merge foundational studies in biology, chemistry and computer science with translational science to produce pioneering drugs and
POSTDOCTORAL ASSOCIATE – Droujinine Lab – Molecular & Cellular Biology
May 23, 2024
Job Category: Postdoctoral Associates/Fellows
Requisition Number: POSTD003117
Schedule: Full Time
Job Location Type: On-siteCA Campus
San Diego, CA, USA
We are seeking a highly motivated Postdoctoral Associate. Ideal candidate will lead their own project, and perform mammalian cell culture, in vivo mouse experiments, in vivo genetic screens, quantitative TMT mass spectrometry proteomics, metabolomics, western blot, pulldowns, DNA cloning, immunostaining, confocal microscopy, high throughput screens, and bioinformatic data analysis. Significant emphasis is placed on the professional development of the Postdoctoral Associate. More information on the project will be discussed during the interview process.
RESEARCH ASSISTANT III – Sanna Lab
Mar 28, 2024
Job Category: Research Staff
Requisition Number: RESEA001403
Schedule: Full TimeCA Campus
San Diego, CA, USA
ABOUT US: Scripps Research is ranked the most influential institution in the world for its impact on innovation. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Scientists in the institute’s five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr to merge foundational studies in biology, chemistry and computer science with translational science to produce pioneering drugs and advance
