The Wistar Institute in the United States invites application for vacant Postdoctoral and Research Positions, an international leader in biomedical science, with special expertise in oncology, immunology, infectious disease and vaccine research.
Post-Doctoral Fellow – Li LabThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Wednesday, August 20, 2025The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The Wistar Institute has an opening for an ambitious and productive Post-Doctoral Fellow to join the laboratory of Dr. Qingsheng Li in The Wistar Institute’s HIV Cure and Viral Diseases Center. We seek to recruit a highly motivated candidate to study HIV-1 immunopathogenesis, latency and cure. The successful candidate will use cutting-edge technologies, including genome editing, spatial scRNA-seq, in vitro and in vivo models and human specimens, to better understand the fundamental biology of HIV-1 latency and to explore novel therapeutic approaches to cure HIV-1 infection. The successful candidate will work in a dynamic scientific environment with ample opportunities for interactions with leading investigators in HIV virology, vaccinology and advanced therapeutics through programmatic funding mechanisms. Candidates should have a Ph.D. (or equivalent) degree. Applicants must have a strong background in one or more of the following disciplines: virology, immunology, molecular and/or cellular biology. Applicants with experience in virology and immunology, especially in HIV-1 studies, are strongly encouraged to apply. Website: https://www.wistar.org/our-scientists/qingsheng-li/ The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. Research discoveries conducted at Wistar have led to the development of vaccines; the identification of genes associated with cancers; and the development of many other significant research technologies and tools. We offer a competitive salary and an excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org.Read MoreReq# 1004
Research Assistant – Montaner LabThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Wednesday, August 20, 2025The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The Wistar Institute has an opening for a Research Assistant to join the lab of Dr. Luis Montaner. The Montaner laboratory combines virological and immune system-based research focused on gene-modified NK cells, HIV infection, and HIV cure-directed research through long-standing community partnerships and clinical trials research. Duties will include lab maintenance (inventory, ordering, lab operations support), whole blood isolation, flowcytometry, ELISAs, work in BSL-2+ (HIV-infected cell cultures), NK-cell assays, molecular biology and cell-mediated assays. A bachelor’s degree in a science-related field (or equivalent) is required. Experience working in a laboratory is preferred. Position level commensurate with experience. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. We offer a competitive salary and excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org. Read MoreReq# 1005
Post-Doctoral Fellow – Sarma LabThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Tuesday, August 19, 2025A Postdoctoral Fellow position is available in the laboratory of Dr. Kavitha Sarma. The Sarma lab investigates mechanisms of gene regulation through RNA-containing chromatin using neurodifferentiation and cancer models. Candidates with strong interest in gene regulation, chromatin architecture, epigenetic mechanisms, and non-coding RNA biology are encouraged to apply. Experience in performing and analyzing data from genomic experiments such as RNA-seq, ChIP-seq, CUT&RUN is required. Candidates should have a PhD (or equivalent) degree and must have at least one first author peer reviewed publication. Interested individuals should apply by submitting: A CV including a list of publications and manuscripts in preparation. One-page cover letter detailing the reason for their scientific interest in the lab, and outline potential postdoctoral research projects, and career goals. Names and contact information for at least 3 references to ksarma@wistar.org The lab is a core member of the Penn Epigenetics Institute which allows interactions and collaborations with many scientists with shared research interests. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources for cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. The Institute is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s single-minded focus is on making discoveries that will change the future of human health. For more details on research and a list of publications visit: http://www.ncbi.nlm.nih.gov/pubmed/?term=Kavitha+SarmaRead MoreReq# 999
Staff Scientist – Montaner LabThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Tuesday, August 19, 2025The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The NCI-designated Ellen and Ronald Caplan Cancer Center together with the Vaccine and Immunotherapy Center at The Wistar Institute are seeking a Cancer Immunotherapy Staff Scientist to join the laboratory of Dr. Luis Montaner. The Montaner lab has an HIV cure-directed research program. The laboratory focuses on: Gene-modified NK cells Cell death pathway regulation Latency reversal Regulation Interferon-alpha versus Interferon-beta, Type-I signaling Ph.D. or equivalent degree required. Three plus years of postdoctoral training, along with a strong publication record in HIV research and cellular immunology, usually evidenced by a minimum of two to three primary-authored, refereed publications in high-quality journals is required. Candidate should have superior research skills and the ability to conduct assigned research with minimal supervision, demonstrating leadership in immunology, virology, and molecular/cellular biology with the ability to supervise others. Experience with bioinformatics, microscopy, cellular immunology, HIV, and flow cytometry is required. It is anticipated that a Staff Scientist will contribute to the intellectual activity of the laboratory through assistance with the writing of grants and publications and participation in seminars. Interested candidates should apply online and include a CV and full publication list, summary of previous research and contact information of three referees. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. We offer a competitive salary and excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org. Read MoreReq# 1006
Research Assistants – Aird LabThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Tuesday, July 22, 2025The Wistar Institute has two openings for Research Assistants to join the laboratory of Dr. Katherine Aird. The Aird lab broadly focuses on tumor metabolism and how metabolic reprogramming and the cell cycle program are interconnected. The lab uses a variety of tumor models, including ovarian cancer and melanoma, to identify new mechanisms and exploit that knowledge for novel cancer therapies. Responsibilities for the successful candidates will involve designing and conducting experiments, analyzing data, data recording, animal experiments, and overall laboratory management. A Bachelor’s degree in a science-related field (or equivalent combination of education and experience) is required. The successful candidates will have a strong understanding of laboratory procedures, excellent technical and organizational skills, and the ability to work independently and as part of a team. Candidates with laboratory experience are encouraged to apply. The available positions are commensurable based on experience. The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting-edge collaborative research and provides outstanding intellectual environments and state-of-the-art facilities. We offer a competitive salary and excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org. Read MoreReq# 1001
Post-Doctoral Fellow – Tempera LabThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Tuesday, July 8, 2025The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The Wistar Institute has an opening for an ambitious and productive Post-Doctoral Fellow to join the laboratory of Dr. Italo Tempera. We seek to recruit a highly motivated candidate to study how chromatin architecture regulates gene expression in the context of cancer. The successful candidate will use cutting-edge technologies, including Hi-C, ChIA-PET, and single-cell sequencing, to explore the function of epigenetic factors in chromatin architecture and how chromatin architecture changes contribute to human viral oncogenesis. The successful candidate will work in a dynamic scientific environment with ample opportunities for interactions with leading investigators in virology, epigenetics, or cancer biology through programmatic funding mechanisms. Applicants must have a strong background in one or more of the following disciplines: virology, biochemistry, molecular and cellular biology, genome-wide approaches to cancer, or bioinformatics. Applicants with experience in tumor viruses, epigenetics, or genome-wide studies are strongly encouraged to apply. Candidates should have a Ph.D. (or equivalent) degree. In addition to the online application, please submit a curriculum vitae and contact details of three references to Dr. Italo Tempera, itempera@wistar.org. Website: https://wistar.org/our-scientists/italo-tempera The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. Research discoveries conducted at Wistar have led to the development of vaccines; the identification of genes associated with cancers; and the development of many other significant research technologies and tools. We offer a competitive salary and an excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org.Read MoreReq# 995
Post-Doctoral Fellows – Nefedova Lab (Immuno-Oncology)The Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Wednesday, July 2, 2025The Wistar Institute has openings for Post-Doctoral Fellows to join the laboratory of Dr. Yulia Nefedova. The Nefedova laboratory focuses on understanding the mechanisms involved in regulation of tumor progression and therapy resistance by tumor microenvironment. We are seeking highly motivated post-doctoral fellows to work on the intersection of basic and translational research in immuno-oncology, focusing on the role of myeloid-derived suppressor cells in solid cancers. The successful candidates will have experience in isolation and analysis of myeloid cell functions, strong hands-on skills in basic cellular and immunological methods, including multi-color flow cytometry, ELISA, cell killing assays, experience with analysis of human samples, and extensive experience with mouse cancer models. A PhD in immunology or cancer biology is required. Candidates should have at least one first-author peer-reviewed publication. Interested individuals should apply by submitting a CV, a one-page cover letter outlining the reason for their scientific interest in the lab and career goals, as well as names and contact information for at least 3 references to Dr. Yulia Nefedova, ynefedova@wistar.org. We offer a competitive salary and an excellent benefits package. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources for cutting-edge collaborative research and provides outstanding intellectual environments and state-of-the-art facilities. The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. For more information about The Wistar Institute, visit our website at www.wistar.org. Read MoreReq# 987
Bioinformatics Technician – Center for Advanced TherapeuticsThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Monday, June 30, 2025The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The Wistar Institute has an opening for a Bioinformatics Technician in the Center for Advanced Therapeutics (“The Center”) to perform a wide variety of laboratory tasks and experiments in a highly interactive and collaborative team. The Center for Advance Therapeutics focuses on cancer, infectious disease and translation research to accelerate the development of novel therapeutics. Successful candidates will have an MS in Bioinformatics/Computational Biology/Biomedical Sciences with coursework related to high throughput data analysis, or equivalent combination of education and experience, required. Prior experience in Matlab or R statistical environments, programming languages Python or Perl and/or in bioinformatics data analysis of high throughput data (next generation sequencing, microarrays, proteomics) is preferred. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. We offer a competitive salary and excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org. Read MoreReq# 994
Post-Doctoral Fellow – Zhang LabThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Tuesday, June 24, 2025The Wistar Institute has an opening for an ambitious and productive Post-Doctoral Fellow to join the laboratory of Dr. Nan Zhang (https://www.wistar.org/our-scientists/nan-zhang/). The Zhang lab explores novel myeloid cell-based immunotherapy against intraperitoneal metastasis of ovarian cancer using mouse models and patient samples as well as state-of-the-art technologies such as spatial multi-omics, multiphoton intravital microscopy, and spectral flow cytometry. Applicants must have a strong background in one or more of the following disciplines: immunology, tumor microenvironment, flow cytometry, fluorescence imaging, mouse models, single-cell RNA sequencing, or molecular and cellular biology. Candidates should have a Ph.D. (or equivalent) degree or should be close to obtaining their doctoral degree. Candidates committed to an academic career are strongly encouraged to apply. In addition to the online application, please submit a curriculum vitae and contact details of three references to Dr. Nan Zhang, nzhang@wistar.org. The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. We offer a competitive salary and excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org.Read MoreReq# 990
Post-Doctoral Fellow – Montaner LabThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Tuesday, June 24, 2025The Wistar Institute has an opening for a highly motivated Post-Doctoral Fellow to join the laboratory of Dr. Luis Montaner in the HIV Cure and Viral Diseases Center. The Montaner lab combines virological and immune system-based research through long-standing community partnerships and clinical trials research, along with using laboratory models of virus infection. The successful candidate will work on inflammasome, pyroptosis and HIV reservoirs. The laboratory focuses on: Regulation of inflammasome and innate immunity. Exploring interface between persistence of HIV reservoirs and immune detection. Developing strategies for eradicate of HIV-1 infection. Personalized HIV cure strategies Further details on the Montaner Laboratory can be viewed on our website: https://www.wistar.org/our-scientists/luis-montaner/ Candidates should have a PhD or equivalent with a strong background in HIV virology, molecular virology, immunology, and molecular/cellular biology. Experience with inflammasomes, molecular screening, bioinformatics, microscopy, and flow cytometry is a plus. The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. We offer a competitive salary and excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org. Read MoreReq# 969
Post-Doctoral Fellow – Auslander LabThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Monday, June 16, 2025A Post-Doctoral Fellow position is open in the laboratory of Dr. Noam Auslander at The Wistar Institute. The Auslander lab employs state-of-the art machine and deep learning techniques to complex biological data, to answer pressing research questions in biomedicine. The lab focuses on developing new methods to understand how microbes modulate immune responses in human diseases, with a focus on cancer. Candidates should have a PhD (or equivalent) degree or should be close to obtaining their doctoral degree. Applicants must have a strong background in one or more of the following disciplines: (1) Immunology, with some prior experience in computational biology (2) Molecular evolution, and in particular for microbial genomics (2) computer science training, with an interest in computational biology. In addition to the online application, please submit a curriculum vitae and contact details of three references to Dr. Auslander via e-mail at nauslander@wistar.org. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. Research discoveries conducted at Wistar have led to the development of vaccines; the identification of genes associated with cancers; and the development of many other significant research technologies and tools. We offer a competitive salary and an excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org.Read MoreReq# 985
Call for New Faculty (Open Rank) for the Center for Advanced Therapeutics in the Broad Areas of Immune Oncology, Autoimmunity or B-Cell BiologyThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Tuesday, May 20, 2025The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health.The Wistar Institute is seeking outstanding faculty candidates in the new Center for Advanced Therapeutics (CAT) to bridge foundational discovery research in immunology, epigenetics, cancer and autoimmunity with new therapeutic approaches. Candidates at the Assistant, Associate and full Professor rank will be considered.We are seeking highly accomplished, motivated and collaborative investigators to lead academic research programs focusing on problems in immune-oncology, autoimmunity, B-cell biology or immune epigenetics to complement ongoing research programs at The Wistar Institute. The ideal candidate will hold a PhD or MD/PhD with demonstrated research accomplishments in immune biology of cancer, autoimmunity, or epigenetics and a strong interest in a therapeutic development of basic research. This may include accomplishments in academic publications and bio/pharma industry experience. The successful candidate is expected to establish an independent, externally funded research program and actively pursue grant support to sustain and grow their laboratory. A strong publication record demonstrating impactful research and scientific leadership will be critical for success in this role.The Wistar Institute is an exceptional institute for advancing a career in research. It is among the most accomplished U.S. institutes in the areas of translational vaccine/biologic research. The Wistar Institute is the nation’s first independent biomedical research Institute with long-standing NCI Cancer Center designation. It has a strong technology transfer focus for biomedical research. The Institute offers a highly competitive start-up package in addition to an outstanding and interactive collaborative research environment.The Institute offers a state-of-the-art vivarium and access to outstanding core facilities in proteomics and metabolomics, genomics, microscopy, high-throughput molecular screening, spatial transcriptomics, medicinal chemistry, bioinformatics, flow cytometry, and humanized mouse models, among others. The Institute’s location is in the University City area of Philadelphia, PA and is adjacent to the campuses of the University of Pennsylvania, Children’s Hospital of Philadelphia, and Drexel University, providing an exceptional work environment for vigorous academic and clinical collaborations. Wistar is a very attractive destination for training opportunities for undergraduate, graduate students, and postdoctoral fellows.Applications will be reviewed as received and will be accepted until the position is filled. To ensure timely consideration, applications will be reviewed using a rolling format. The application should include: a curriculum vitae, a summary of past and future research interests (no more than 3 pages), and history of accomplishments, talks and research funding support (as applicable). Applications (submitted as a single PDF) should be sent by e-mail to: Maria Colelli, Faculty Search Coordinator, (mcolelli@wistar.org), The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104.Read MoreReq# 981
Administrative Coordinator – Center for Advanced TherapeuticsThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Monday, May 19, 2025The Wistar Institute has an opening for an Administrative Coordinator in our new Center for Advanced Therapeutics (“The Center”). The Center will focus on early-stage drug discovery that bridges innovation in immunotherapy and vaccine biology to accelerate next-generation therapies and medicines. The core scientific objectives of the Center for Advanced Therapeutics will be fueled by collaborative research in immunology, next- generation sequencing technologies, chemical and structural biology, and computational, artificial intelligence (AI)-driven systems. The Administrative Coordinator is a front-facing position reporting to the Director of The Center whose job responsibilities include welcoming guests to The Center as well as providing secretarial, administrative, purchasing, and laboratory management support to Center faculty and members. The successful candidate will serve as a key resource for new and current laboratory members by providing essential information and guidance related to The Center, laboratory, and institutional policies, practices, and operations. The individual will manage the Center Director’s calendar, coordinate schedules for conferences, meetings, and appointments, as well as oversee travel arrangements (transportation, reservations, itineraries, and reimbursements). Additionally, the Administrative Coordinator manages the regular Center meeting schedule and prepares a variety of documents including correspondence, memoranda, journal reviews, and other documents as requested. The role also includes assisting with the recruitment process for new Center faculty and personnel with resume review and interview coordination. The ideal candidate will have prior experience and demonstrated success working in a front office position in an academic environment and display excellent attention to detail, good judgment, awareness of the need to serve as a first-person of contact for the Center, the ability to work independently with limited direction, demonstrate initiative, strong interpersonal skills, excellent written and verbal communication skills, and excellent organization. High school diploma or equivalent required. Bachelor’s degree preferred. Candidates with a minimum of 3 years of high-level secretarial/administrative experience and a proven level of responsibility are strongly preferred. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. The new HIV Cure and Viral Diseases Center will be located at The Wistar Institute North location at 3675 Market Street. Wistar provides resources to its faculty and staff that enable them to conduct cutting-edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. Research discoveries conducted at Wistar have led to the development of vaccines; the identification of genes associated with cancers; and the development of many other significant research technologies and tools. We offer a competitive salary and an excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org.Read MoreReq# 979
Faculty Position in Academic Drug Discovery (Open Rank)The Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Wednesday, May 7, 2025The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The Wistar Institute is seeking outstanding faculty candidates in the new Center for Advanced Therapeutics (CAT) to bridge foundational discovery research with small molecule drug discovery. Candidates at the Assistant, Associate and full Professor level will be considered. We are seeking a highly productive academic and/or biopharma trained investigator with research interests in academic drug discovery, including the broad areas of chemical biology, medicinal chemistry, structure-based design, computational chemistry, and/or target identification. The ideal candidate will hold a PhD in synthetic organic chemistry and/or medicinal chemistry and have demonstrated, through peer-reviewed publications, the ability to design, synthesize, and utilize small molecule regents to probe interesting biological questions including the successful demonstration of the synthesis of novel small molecule probes to further the mechanistic understanding of biological processes. This may include experience in medicinal chemistry and the demonstrated ability to define structure activity relationships utilizing biochemical and cell-based assays to determine affinity, understanding physiochemical properties, and the ability to define selectivity for a chemical series. Applicants who have a trajectory toward or have established independent research supported by extramural funding are of high priority. The successful candidate is expected to establish an independent, externally funded research program and actively pursue grant support to sustain and grow their laboratory. A strong publication record demonstrating impactful research and scientific leadership will be critical for success in this role. The Wistar Institute is an exceptional institute for advancing a career in research. It is among the most accomplished U.S. institutes in the areas of translational vaccine/biologic research. The Wistar Institute is the nation’s first independent biomedical research Institute with long-standing NCI Cancer Center designation. It has a strong technology transfer focus for biomedical research. The Institute offers a highly competitive start-up package in addition to an outstanding and interactive collaborative research environment. The Institute offers a state-of-the-art vivarium and access to outstanding core facilities in proteomics and metabolomics, genomics, microscopy, high-throughput molecular screening, spatial transcriptomics, medicinal chemistry, bioinformatics, flow cytometry, and humanized mouse models, among others. The Institute’s location is in the University City area of Philadelphia, PA and is adjacent to the campuses of the University of Pennsylvania, Children’s Hospital of Philadelphia, and Drexel University, providing an exceptional work environment for vigorous academic and clinical collaborations. Wistar is a very attractive destination for training opportunities for undergraduate, graduate students, and postdoctoral fellows. Applications will be reviewed as received and will be accepted until the position is filled. To ensure timely consideration, applications will be reviewed using a rolling format. The application should include: a curriculum vitae, a summary of past and future research interests (no more than 3 pages), and history of accomplishments, talks and research funding support (as applicable). Applications (submitted as a single PDF) should be sent by e-mail to: Maria Colelli, Faculty Search Coordinator, (mcolelli@wistar.org), The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104. For more information about The Wistar Institute please visit our website at www.wistar.org. Read MoreReq# 976
Managing Director – ImagingThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Tuesday, April 29, 2025The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The Wistar Institute has an upcoming opening in the Imaging Shared Resource (i.e., “Core” or “Facility”) for the Managing Director position. The successful candidate will overlap with the current Managing Director for a period of six months to ensure a seamless transition. The Managing Director will lead the day-to-day operations of the Imaging Shared Resource of The Wistar Institute, including management of the Facility staff. The Core provides all Wistar investigators with access to traditional and advanced optical systems capable of imaging complex cellular structures and elucidating the temporal and spatial organization of regulatory events within cells, tissues, and organisms. The Facility also offers expert technical assistance with advanced image analysis solutions. The Managing Director will be expected to advise and coordinate work/facilitate projects with clients with the assistance of the Core’s staff and in collaboration with the Core’s Scientific Director Duties and Responsibilities Perform and oversee imaging services for fixed and live specimens on a variety of microscopy and specialty imaging platforms, including Nikon NiE, TiE, 80i, TE2000, and TE300 widefield microscopy systems, a Leica Mica Widefocal automated microscope, Leica SP8 WLL and Stellaris 8 WLL confocal laser scanning microscopes, a Stellaris 8 3X TauSTED super-resolution confocal microscope, a Leica SP8 2-photon intravital microscope, a Hamamatsu S60 Nanozoomer whole slide scanner, and traditional photographic techniques with a Nikon Z6II digital camera system. Perform and assist with multidimensional analysis of acquired images using a variety of software packages, including Nikon Elements AR with AI module, Leica LAS-X, Leica Aivia, SVI Huygens deconvolution software,e and Image J (FIJI). Provide training for Wistar technical and research staff in the use of facility instrumentation and software. Coordinate with the Co-Managing Director to support pre-clinical imaging using a Revvity IVIS SpectrumCT, Revvity Vega high-throughput ultrasound, and whole-body or targeted radiotherapy using an Xstrahl Small Animal Radiation Research Platform (SARRP). Create, train, and assist with publication-quality figures of scientific images. Oversee daily operations of the facility and maintain equipment and infrastructure. Supervise and train core facility research assistant(s). Maintain a working knowledge of all equipment and technical aspects of the services offered by the Facility. Maintain “state of the art” capabilities of the equipment and services provided by the facility and develop new techniques as needed. Provide up-to-date facility records and preparation of monthly reports. Manage iLab, the software tool for Core Facility Operation and associated billing events/financial management for imaging instrumentation. Communicate with investigators to fully understand their imaging needs, inform them of the capabilities of the core, and help integrate the facility with their existing research programs. Actively solicits users and maximizes the efficiency of operation and utilization of the facility. Coordinate with Wistar faculty to identify gaps in current imaging instrumentation and develop proposals to support the acquisition of new equipment to support those needs. Develop working relationships with colleagues in nearby facilities for information sharing and mutual support. Performs other duties as assigned. A Bachelor’s or Master’s degree in Biology, Physics, Bioengineering, or a related scientific discipline with 5 to 7 years of experience or a PhD in Biology, Physics, Bioengineering, or a related scientific discipline is required. At least 10 years of experience in an imaging core facility, including operation of multi-dimensional, brightfield, and fluorescence microscopes using widefield and confocal systems with live and fixed samples. Experience with advanced confocal techniques, including super-resolution (STED), Fluorescence Lifetime Imaging (FLIM), Förster resonance energy transfer (FRET), and others, is desired. Experience with 2-photon intravital imaging is a plus. Advanced knowledge of image analysis platforms and computer hardware integration with high content and high throughput systems is strongly desired. Traditional photographic skills for macro to full-sized subjects is also preferred. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting-edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities.We offer a competitive salary and an excellent benefits package. For more information about The Wistar Institute, visit our website at www.wistar.org. Read MoreReq# 951
Post-Doctoral Fellow – Liang LabThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Wednesday, April 23, 2025Qualified and highly motivated Post-Doctoral Fellow candidates are invited to apply to the laboratory of Dr. Chengyu Liang at The Wistar Institute, the first National Cancer Institute (NCI)-designated basic cancer center. Research in the Liang Lab focuses on understanding the basic principles of cellular processes to answer key questions in cancer development and viral infectious disease. The Liang lab has an opening for a Post-Doctoral Fellow to study stem cell biology in colitis and lymphoblastic leukemia using state-of-the-art techniques such as 3D platform and respective animal models; and dissecting the molecular mechanisms of virus-host interaction and their translational application. The Liang lab is a multi-disciplinary and highly interactive team. The successful candidate will be expected to conduct independent and challenging research and work in a highly collaborative manner. Projects will discover potential new targets to guide the personalized treatment of devastating human cancers of unmet need. For more information on the Liang lab, please visit: https://www.wistar.org/our-scientists/chengyu-liang/ Recent PhD graduates from related fields with a record of peer-reviewed publications, strong laboratory experience including penetrating knowledge of molecular and cellular biology, biochemistry, immunology, or related disciplines are encouraged to apply. Candidates who have demonstrated the ability to complete complex research projects will be considered. Prior experience with 3D culture, infection model, mice experiments and bioinformatics skills preferred. In addition to the online application, please submit a curriculum vitae and contact details of three references to Dr. Chengyu Liang, cliang@wistar.org. The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. We offer a competitive salary and excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org.Read MoreReq# 968
Research Assistant – Lieberman LabThe Wistar Institute, Philadelphia, Pennsylvania, United States of AmericaPosted Friday, March 21, 2025The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health. The Wistar Institute has an opening for a Research Assistant to join the laboratory of Dr. Paul Lieberman. Responsibilities for the successful candidate may include: managing lab operations, along with managing lab supplies and instrumentation; and assisting with molecular and cellular biology experiments. A Bachelor’s degree in a science-related field (or equivalent combination of education and experience) is required. Basic molecular and cell biology experience is required. Familiarity with cell culture, Western blotting, recombinant DNA, and protein purification is preferred. The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting-edge collaborative research and provides outstanding intellectual environments and state-of-the-art facilities. We offer a competitive salary and excellent benefits package. For more information about The Wistar Institute visit our website at www.wistar.org. Read More
